Optimized for quick response and low latency (Gaming):

• Disable Interrupt Moderation Rate (if not possible decrease the size)
• Disable Offload TCP Segmentation
• Increase Transmit Descriptors
• Increase Receive Descriptors
• Increase RSS Queues

Optimized for throughput (e.g. Servers):

• Enable Jumbo Frames
• Increase Transmit Descriptors
• Increase Receive Descriptors

For low CPU utilization:

• Maximize Interrupt Moderation Rate
• Keep Receive Descriptors at default
• Avoid setting large Receive Descriptors
• Decrease RSS Queues
• Decrease the Max number of RSS CPUs in Hyper-V environments

Optional disable/change the following in your Network Adapter

• Disable Adaptive Inter-Frame Spacing
• Disable Flow Control
• Disable Interrupt Moderation
• Set Interrupt Moderation Rate to OFF (not needed if you disable Interrupt Moderation)
• Set Enable PME to Disabled
• Disable all “Offload” features
• Disable Packet Priority & VLAN
• Disable Jumbo Packet
• Set Receive Side Scaling (RSS) – ENABLED
• RSS Balancing Mode – NUMAScaling
• Don’t touch Speed & Duplex, leave it on Auto Negotiation

tweaks via CMD/PowerShell

netsh interface teredo set state disabled
netsh interface 6to4 set state disabled
netsh winsock reset
netsh interface isatap set state disable
netsh int tcp set global timestamps=disabled
netsh int tcp set heuristics disabled
netsh int tcp set global autotuninglevel=disable
netsh int tcp set global congestionprovider=ctcp
netsh int tcp set supplemental Internet congestionprovider=CTCP
netsh int tcp set global chimney=disabled
netsh int tcp set global ecncapability=disabled
netsh int tcp set global rss=enabled
netsh int tcp set global rsc=disabled
netsh int tcp set global dca=enabled
netsh int tcp set global netdma=enabled
PowerShell Disable-NetAdapterChecksumOffload -Name "*"
PowerShell Disable-NetAdapterLso -Name "*"
PowerShell Disable-NetAdapterRsc -Name "*"
PowerShell Disable-NetAdapterIPsecOffload -Name "*"
PowerShell Disable-NetAdapterPowerManagement -Name "*"
PowerShell Disable-NetAdapterQos -Name "*"